Tizanidine-d<sub>4</sub> (hydro<wbr/>chloride)

Tizanidine-d4 (hydrochloride)

CAT N°: 26521
Price:

From 231.00 196.35

Tizanidine-d4 is intended for use as an internal standard for the quantification of tizanidine (Item No. 16477) by GC- or LC-MS. Tizanidine is an ?2-adrenergic receptor (?2-AR) agonist.{39278} Administration of tizanidine reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats. Tizanidine-induced neuronal depression is reversed by the selective ?2-AR antagonist RX781094 but not the ?1-AR antagonists prazosin (Item No. 15023) and WB-4101. It acts as a muscle relaxant that inhibits ?- and ?-rigidity in rats, reflex muscle tone in rabbits, and the linguomadibular reflex in cats without sedative, hemodynamic, or neurochemical effects.{39279} Formulations containing tizanidine have been used for the treatment of stiff-person syndrome and to improve gait function in patients with incomplete spinal cord injuries.{39280,39281}

We also advise you

TAF 10 Peptide

TAF 10 Peptide

TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
View