Tilmicosin-d<sub>3</sub>

Tilmicosin-d3

CAT N°: 33545
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Tilmicosin-d3 is intended for use as an internal standard for the quantification of tilmicosin (Item No. 18190) by GC- or LC-MS. Tilmicosin is a macrolide antibiotic.{27769} It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity.{61661} Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.

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