Talniflumate

Talniflumate

CAT N°: 29623
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Talniflumate is a prodrug form of the COX-2 inhibitor niflumic acid (Item No. 70650).{53157} It decreases the rate of chloride/bicarbonate exchange by 55% in isolated mouse intestinal villous epithelial cells when used at a concentration of 100 µM.{53158} Dietary administration of talniflumate (88 mg/kg per day) increases survival but has no effect on the number of crypt goblet cells in the jejunum or cecum in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

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