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TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation.{41744} It is cardiomyogenic at concentrations less than 5 ?M, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1? (CK1?) and CK1? and reduces expression of Wnt/?-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1784751-18-3 |
| Molecular formula | C20H12F3N3 |
| Smiles | FC1=CC=CC(F)=C1C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2 |
| Molecular weight | 351,3 |
| Custom code | 2933.39 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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