From €202.00 €171.70
Secretory phospholipase A2 (sPLA2) (Type IB) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G1B in humans.{56210} It is composed of an N-terminal signal peptide, a highly-conserved calcium-binding loop, a catalytic domain, an sPLA2 Type I-specific disulfide bond that provides stability, and a pancreatic loop. It is primarily expressed in the pancreas but is also expressed in the lung.{64639} Upon activation, sPLA2 (Type IB) is released into the extracellular space and preferentially hydrolyzes phosphatidylglycerol (PG), phosphatidylcholine (PC), and phosphatidic acid (PA), over phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylinositol (PI).{12333} It is involved in lipid nutrient digestion and absorption and also has anthelmintic activity.{64640} Pla2g1b-/- mice fed a high-fat diet are resistant to obesity and have decreased blood glucose and serum insulin levels and increased fecal lipid levels.{64641} Mutations in PLA2G1B are associated with central adiposity and colorectal cancer.{64640} Cayman’s sPLA2 (Type IB) Rabbit Monoclonal Antibody (Clone 004) can be used for ELISA.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 ml, 100 µl, 50 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | |
| Antigen | Recombinant mouse sPLA2 (Type IB) |
| Host | Rabbit |
| Clone | 4 |
| Isotype | IgG |
| Custom code | 3822.19 |
| Application(s) | ELISA |
| Formulation | 50 or 100 µl, or 1 ml of protein A-affinity purified monoclonal antibody |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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