€615.00 €522.75
Sox2 is a transcription factor and member of the SoxB1 group of Sox proteins.{58856} It is composed of an N-terminal domain, an HMG domain responsible for DNA binding, and a C-terminal transactivation domain.{58857} Sox2 is expressed in pluripotent blastocyst cells, ectodermal, endodermal, and mesodermal cells and the tissues derived from them, primordial germ cells, and stem and progenitor cells in adult organisms, including in the neurogenic regions of the adult brain.{58856} It is involved in neural commitment, organ specification, hair follicle differentiation, and osteoblast proliferation during development either directly or by indirectly inhibiting other transcriptional regulators. Sox2 is required for the maintenance of neural stem cells (NSCs) in the subgranular zone of the adult hippocampal dentate gyrus.{58858} It has been used as a reprogramming factor in the generation of induced neural stem cells (iNSC) from fibroblasts and, in combination with the transcription factors Klf4, Oct4, and c-Myc, in the generation of induced pluripotent stem cells (iPSCs) from fibroblasts.{58856} Heterozygous mutations for SOX2 are associated with anophthalmia-esophageal-genital (AEG) syndrome, a disorder characterized by anophthalmia or microphthalmia, fistula between the trachea and esophagus, and brain abnormalities.{58856,58857} Gene amplification of SOX2 has been found in patients with glioblastoma, lung cancers, sinonasal cancer, and squamous cell carcinomas and is associated with favorable prognosis, relapse, or metastasis depending on the cancer type.{58857} Cayman’s Sox2 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of human Sox2 |
| Clone | RM427 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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