€474.00 €402.90
Serum retinol binding protein 4 (sRBP4) binds one equivalent of vitamin A and is one of the major retinol carriers found in the blood of mammals.{14372, 14373} Human RBP4 is a monomeric 21 kDa ?-sheet-rich protein that contains three disulfide bonds and belongs to the lipocalin protein family.{14379} sRBP4 is synthesized and sequestered in hepatocytes until retinol binding triggers its secretion.{14379} In plasma, sRBP4 typically forms a 1:1 complex with the 55 kDa tetrameric protein transthyretin (TTR) which prevents RBP from being removed from the plasma by glomerular filtration.{14378} Recent studies have shown that sRBP4 is an adipocyte-derived “signal” that may contribute to the pathogenesis of type 2 diabetes.{14371, 14380} Elevation of sRBP4 causes systemic insulin resistance whereas reduction of serum concentrations improves insulin action.{14371, 14376, 14374} The highest known concentrations of this protein exist in serum, liver, and skeletal muscle.{14374,14375,149371}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 500 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | human sRBP4 amino acids 28-37 (RVKENFDKAR) |
| Application(s) | WB |
| Formulation | Peptide affinity-purified IgG |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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