β-Secretase Inhibitor IV

β-Secretase Inhibitor IV

CAT N°: 23388
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From 202.00 171.70

?-Secretase inhibitor IV is an inhibitor of ?-site amyloid protein cleaving enzymes (BACE/?-secretase) 1 and 2 (IC50s = 15 and 230 nM for human BACE1 and 2, respectively).{16820} It has >500-fold selectivity for BACE1 and 2 over the aspartyl proteases renin and cathepsin D. ?-Secretase inhibitor IV inhibits secretion of amyloid-? (A?) precursor protein (APP; IC50 = 29 nM) in HEK293T cells transfected with a truncated APP. It also inhibits formation of the A? peptides A?38, A?40, and A?42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively).{40417}

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