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Rubimaillin is a naphthohydroquinone that has been found in R. cordifolia with diverse biological activities.{45334,45335,45336,45337} It inhibits the growth of E. coli and S. aureus in a disc assay when used at a concentration of 100 ?g per disc.{45334} Rubimaillin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay (IC50 = 0.7 ?M). It inhibits acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and ACAT2 (IC50s = 80 and 22 ?M, respectively) and cholesterol ester synthesis (IC50 = 18 ?M) in murine macrophages.{45335} Rubimaillin increases osteoblastic differentiation of C2C12 mesenchymal progenitor cells induced by bone morphogenic protein 2 (BMP2) and enhances skeletal development in zebrafish larvae.{45336} It inhibits TNF-?-induced NF-?B reporter gene expression and nuclear translocation of p65 and potentiates TNF-?-induced apoptosis in HeLa cells.{45337} Rubimaillin (25 and 75 mg/kg) reduces tumor growth in a HeLa mouse xenograft model.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 25 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 55481-88-4 |
| Molecular formula | C17H16O4 |
| Smiles | OC1=C2C(C=CC=C2)=C3C(C=CC(C)(C)O3)=C1C(OC)=O |
| Molecular weight | 284,3 |
| Custom code | 2907.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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