RGDS Peptide

RGDS Peptide

CAT N°: 15359
Price:

From 74.00 62.90

Fibronectin is an extracellular matrix protein which binds other proteins and interacts with cells, serving roles in cell adhesion, migration, and signaling.{5588} Like vitronectin and collagen, fibronectin contains a conserved tripeptide sequence, Arg-Gly-Asp (RGD) to associate with integrins on the cell surface.{3775} RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen ?, and von Willebrand factor, but not vitronectin or collagen.{25165,25162} RGDS interacts with ?5?1 and ?V?3 integrins.{25166} This tetrapeptide interferes with the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM).{25165,25162} It also blocks the attachment of certain pathogens to cells.{25163,25164} RGDS peptide inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen ?, and von Willebrand factor (IC50 = ~10 ?M).{25165,25167,25168} The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in ways that are cell- and stimulus-specific.{25170,25169}

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