Quin-2 AM

Quin-2 AM

CAT N°: 20422
Price:

165.00 140.25

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Item No. 20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM.{31959} It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH.{31959} High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells.{31959,23813} Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.

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