PTC-<wbr/>209

PTC-209

CAT N°: 16277
Price:

From 43.00 36.55

Polycomb complex protein BMI-1 is a polycomb ring finger oncogene that regulates the p16 and p19 cell cycle inhibitor genes. It is necessary for efficient self-renewing cell divisions of stem cells in several tissues and can be over-expressed in tumors. PTC-209 is a BMI-1 inhibitor (IC50 = ~ 0.5 ?M) that irreversibly impairs colorectal cancer-initiating cell (CIC) growth.{28288} It reduces tumor growth in CIC xenograft assays and abrogates colorectal cancer cell self-renewal in vivo, reducing their tumorigenic potential.{28288}

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