Pravadoline

Pravadoline

CAT N°: 10006973
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Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.{13045} Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 ?M in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).{13045} In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 ?M), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.{13045} Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.{13045}

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