Neostigmine (methyl sulfate)

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Cat No: 23501

Biochemicals - Small Molecule Inhibitors

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM).{40760} In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently in...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-benzenaminium, methyl sulfate

Correlated keywords:

59-99-4 59954-03-9 Eustigmin GD65 GD-65 Hodostin Intrastigmina Kirkstigmine Leostigmine Metastigmin NSC93753 Neoeserine Neostigmeth methosulfate Normastigmin Philostigmin Polstigmine Proserine Prostigmine Stiglyn Stigmanol Stigmosan Synstigmine Syntostigmin Vagostigmine prostigmin

Product Overview:
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM).{40760} In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively).{40761} Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block.{40762} Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.

Size	500 mg
Shipping	dry ice
CAS Number	51-60-5
Molecular Formula	C₁₂H₁₉N₂O₂ • CH₃SO₄
SMILES	C[N+](C)(C)C1=CC=CC(OC(N(C)C)=O)=C1.[O-]S(=O)(OC)=O
Molecular Weight	334,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2924.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.