S-trityl-L-Cysteine

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S-trityl-L-Cysteine

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Cat No: 23236

Biochemicals - Small Molecule Inhibitors

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation.{37191} S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-st...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

S-(triphenylmethyl)-L-cysteine

Correlated keywords:

910544-70-6 NSC83265 strityllcysteine tritylthioalanine STLC Kif-11 Eg-5 xenopus tritylcysteine Kif-11 NCI60

Product Overview:
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation.{37191} S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively).{37190} It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay.{37191} It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 µM) and in mouse xenograft models.{37191}

Size	1 g
Shipping	dry ice
CAS Number	07/07/2799 00:00
Molecular Formula	C₂₂H₂₁NO₂S
SMILES	N[C@H](C(O)=O)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Weight	363,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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