Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Urolithin A

  • Zoom
    Urolithin A
  • Urolithin A
Cat No: 22607
Biochemicals - Natural Products
Cayman

Urolithin A is a secondary metabolite of ellagic acid (Item No. 10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.{40131} It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endo...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one
Correlated keywords:
  • 3,8-Hydroxydibenzo-?-pyrone ellagitannin fruit pomegranate caenorhabditis Caco2 SW-480 HT29 dihydroxyurolithin
Product Overview:
Urolithin A is a secondary metabolite of ellagic acid (Item No. 10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.{40131} It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression.{40132} It also potentiates the antiproliferative effect of 5-fluorouracil (Item No. 14416) in Caco-2, SW480, and HT-29 cells.{40128} In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin E2 (PGE2; Item No. 14010) levels and preventing upregulation of COX-2 gene expression and protein levels in colonic mucosa.{40129} It also induces mitophagy in C. elegans, C2C12 myoblasts, and Mode-K intestinal cells in correlation with improved fitness and extended lifespan in C. elegans and increased exercise capacity in mice.{40130}
Size 1 mg
Shipping dry ice
CAS Number 1143-70-0
Molecular Formula C13H8O4
SMILES OC(C=C1)=CC2=C1C3=CC=C(O)C=C3C(O2)=O
Molecular Weight 228,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Urolithin A There are 6 products.

Search