4?8C - C11H8O4 - Bertin Bioreagent

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4?8C

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Cat No: 22110

Biochemicals - Small Molecule Inhibitors

4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

Correlated keywords:

8-formyl-7-hydroxy-4-methylcoumarin 8-formyl-4-methylumbelliferone IRE-1 Xbp IL6 IL4 TNF?

Product Overview:
4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}

Size	5 mg
Shipping	dry ice
CAS Number	14003-96-4
Molecular Formula	C₁₁H₈O₄
SMILES	OC1=CC=C(C(C)=CC(O2)=O)C2=C1C=O
Molecular Weight	204,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.