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Paclitaxel-d5

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    Paclitaxel-d<sub>5</sub>
  • Paclitaxel-d<sub>5</sub>
Cat No: 22092
Biochemicals - Isotopically Labeled Standards
Cayman

Paclitaxel-d5 contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel (Item No. 10461) using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC50 values rangi...

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: 1 mg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • ?S-(benzoyl-2,3,4,5,6-d5-amino)-?R-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Correlated keywords:
  • NSC125973 NSC-125973 abraxane genaxol genetaxyl oncogel onxal pacliex yewtaxan deuterated deuterium gases chromatography isotope GC/MS LC/MS GCMS LCMS Bcl2 G-1 ABI-007 ABI007 BMS-181339-01 BMS181339-01 BMS18133901 18133901 GC-MS capxol coroflex please cyclopax cynviloq cypher select DHP107 DHP-107 ebetaxel emPAC endoTAG endoTAG1 genexol-PM IG-001 002 IG001 IG002 infinnium entaxel LEP-ETU LEPETU MBT-0206 MBT0206 mitotax NK-105 NK105 nab nanotax nanoxel PTX padexol paxene plaxicel QW8184 QW-8184 sindaxel taxus express stent taxalbin taxol taxus liberte tocosol zisu CDK PK b cell lymphoma leukemia
Product Overview:
Paclitaxel-d5 contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel (Item No. 10461) using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC50 values ranging from 2.5-7.5 nM.{18505} It disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1.{18494} It also initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.{18495}
Size 1 mg
Shipping dry ice
CAS Number 1129540-33-5
Molecular Formula C47H46D5NO14
SMILES O=C([C@H](OC(C)=O)C1=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)C3=CC=CC=C3)=O)C[C@]([C@H]4OC(C5=CC=CC=C5)=O)(O)C1(C)C)[C@@]6(C)[C@@]4([H])[C@@]7(OC(C)=O)[C@H](OC7)C[C@@H]6O
Molecular Weight 859
Formulation A solid
Purity ≥99% deuterated forms (d1-d5)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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