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Ansatrienin B

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    Ansatrienin B
  • Ansatrienin B
Cat No: 21996
Cayman

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis.{37029},{37026} In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a mea...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-(cyclohexylcarbonyl)-D-alanine, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
Correlated keywords:
  • 80111-48-4 86992-53-2 171013-74-4 T-23II T23II MTNII MTN-II SDZ115962 115962 anti-biotic fungal streptomyces pp60-csrc TNFa ICAM1
Product Overview:
Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis.{37029},{37026} In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM).{37028} It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells).{37025} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil (Item No. 14416), cisplatin (Item No. 13119), bleomycin (Item No. 13877), mitomycin C (Item No. 11435), and 6-mercaptopurine.{37027} Ansatrienin B is a hydroquinone form of ansatrienin A (Item No. 21995).{37026}
Size 1 mg
Shipping dry ice
CAS Number 82189-04-6
Molecular Formula C36H50N2O8
SMILES O=C(N[C@H](C)C(O[C@H]([C@H](C)[C@@H](O)/C(C)=C\CCC1=CC(O)=CC(N2)=C1O)C/C=C/C=C/C=C/[C@H](OC)CC2=O)=O)C3CCCCC3
Molecular Weight 638,8
Formulation A powder
Purity ≥95%
Custom Code 2907.29
UNSPSC code 12352100

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