6-hydroxy Melatonin

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6-hydroxy Melatonin

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Cat No: 21857

Biochemicals - Receptor Pharmacology

6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).{26017,34286,30338,60504,60505} It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{60506} 6-hydroxy Melatonin is a melatonin 1A (...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]-acetamide

Correlated keywords:

hydroxymelatonin MT-1 2 anti-oxidative anti-oxidant ROS 6OH-mel OHmel 6OHM Interleukin IL6 IL8 NF?B MT 1B

Product Overview:
6-hydroxy Melatonin is an active metabolite of melatonin (Item No. 14427).{26017,34286,30338,60504,60505} It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes.{60506} 6-hydroxy Melatonin is a melatonin 1A (MT1A), MT1B, and MT2 receptor agonist.{26017,34286} It inhibits dopamine release from isolated rabbit retina (IC50 = 0.0016 µM).{30338} 6-hydroxy Melatonin (10 and 100 µM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis.{60504} It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.{60505}

Size	1 mg
Shipping	dry ice
CAS Number	2208-41-5
Molecular Formula	C₁₃H₁₆N₂O₃
SMILES	COC1=C(O)C=C(NC=C2CCNC(C)=O)C2=C1
Molecular Weight	248,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.