8-hydroxy Loxapine

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8-hydroxy Loxapine

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Cat No: 21786

Biochemicals - Receptor Pharmacology

8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine (Item No. 20760), an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2.{24252,36038} Loxapine displays high affinity for histamine, serotonin (5-HT), do...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-chloro-11-(4-methyl-1-piperazinyl)-dibenz[b,f][1,4]oxazepin-8-ol

Correlated keywords:

hydroxyloxapine anti-psychotic 5HT a1A 8OH CYP450 CY-P1A2 5HT2A 5HT2C a1

Product Overview:
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine (Item No. 20760), an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2.{24252,36038} Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively).{24252,24253} It reduces agitation associated with schizophrenia or bipolar disorder.{32724} 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).{36039}

Size	500 µg
Shipping	dry ice
CAS Number	61443-77-4
Molecular Formula	C₁₈H₁₈ClN₃O₂
SMILES	ClC1=CC2=C(C=C1)OC3=C(C=C(O)C=C3)N=C2N4CCN(C)CC4
Molecular Weight	343,8
Formulation	A solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.