Conglobatin

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Conglobatin

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Cat No: 21766

Biochemicals - Natural Products

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus.{39047} It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 brea...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3E,5R,11E)-3,5,7S,11,13R,15S-hexamethyl-8S,16S-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

Correlated keywords:

95273-58-8 FW04 FW04806 04806 FW-04-806 streptomyces hsp-90 cdc-37 cochaperone SKBR3 her-2 human epidermal growth factor receptor kyse-510 b1 b-1 anti-cancer

Product Overview:
Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus.{39047} It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells.{39043} It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 µM, respectively) and decreases the number of invasive cells in vitro.{39043,39046} When combined with lapatinib (Item No. 11493), tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone.{39044} Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 µM).{39045} It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

Size	500 µg
Shipping	dry ice
CAS Number	72263-05-9
Molecular Formula	C₂₈H₃₈N₂O₆
SMILES	C[C@H]([C@H](CC1=CN=CO1)OC(/C(C)=C/[C@H](C)C[C@H](C)[C@H](CC2=CN=CO2)O3)=O)C[C@@H](C)/C=C(C)\C3=O
Molecular Weight	498,6
Formulation	A solid
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.