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Glycoursodeoxycholic Acid

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    Glycourso<wbr/>deoxycholic Acid
  • Glycourso<wbr/>deoxycholic Acid
Cat No: 21698
Cayman

Glycoursodeoxycholic acid (GUDCA) is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid (UDCA; Item No. 15121).{48223,34418} It has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons.{3441...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-[(3?,5?,7?)-3,7-dihydroxy-24-oxocholan-24-yl]-glycine
Correlated keywords:
  • 474-26-0 2273-95-2 anti-oxidant ursodeoxycholylglycine glyclursodeoxycholic akkermansia GUD CA UD hyper-bilirubinemia
Product Overview:
Glycoursodeoxycholic acid (GUDCA) is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid (UDCA; Item No. 15121).{48223,34418} It has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons.{34417,34415} GUDCA reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia.{34416} Oral administration of GUDCA (500 mg/kg per day) decreases the severity of symptoms and increases the amount of A. muciniphila, a bacterial species commonly decreased in patients with inflammatory bowel disease (IBD), in a mouse model of colitis.{34418}
Size 100 mg
Shipping dry ice
CAS Number 64480-66-6
Molecular Formula C26H43NO5
SMILES C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Weight 449,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2924.29
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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