Aristolochic Acid

Confirm delete?

Aristolochic Acid

Zoom

Cat No: 21520

Biochemicals - Natural Products

Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner i...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8-methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid

Correlated keywords:

12770-90-0 61117-05-3 1414787-57-7 NSC11926 NSC50413 TR1736 1 TR 1736 PLIa PLX PLIb AA timeresurus

Product Overview:
Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).{34789} It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.{812} Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.{667} Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.{34790}

Size	10 mg
Shipping	dry ice
CAS Number	313-67-7
Molecular Formula	C₁₇H₁₁NO₇
SMILES	COC1=C(C=C([N+]([O-])=O)C2=C3C4=C(OCO4)C=C2C(O)=O)C3=CC=C1
Molecular Weight	341,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2916.39
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.