Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

AHU377 (calcium salt)

  • Zoom
    AHU377 (calcium salt)
  • AHU377 (calcium salt)
Cat No: 21473
Biochemicals - Small Molecule Inhibitors
Cayman

AHU377 is a methyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, resp...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (?R,?S)-?-[(3-carboxy-1-oxopropyl)amino]-?-methyl-[1,1’-biphenyl]-4-pentanoic acid, 4-ethyl ester, hemicalcium salt
Correlated keywords:
  • AHU-377 neutral endopeptidase LBQ-657 endothelin1 anti-hypertensive 149709-62-6 pro-drug ang at2 at-2 nep
Product Overview:
AHU377 is a methyl ester prodrug from of the neprilysin inhibitor LBQ657 (Item No. 19829).{42277} It increases plasma levels of atrial natriuretic factor (ANF) in conscious rats and anesthetized dogs when administered at doses of 10 and 30 mg/kg, respectively. AHU377 (30 mg/kg) increases ANF-induced urinary sodium excretion in anesthetized rats. Formulations containing AHU377 in combination with valsartan have been used for the treatment of mild to moderate hypertension and chronic heart failure.
Size 10 mg
Shipping dry ice
CAS Number 1369773-39-6
Molecular Formula C24H28NO5 • 1/2Ca
SMILES C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.[Ca+2]
Molecular Weight 430,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : AHU377 (calcium salt) There are 7 products.

Search