MDL 11939

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MDL 11939

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Cat No: 21414

Biochemicals - Receptor Pharmacology

MDL 11939 is a potent, orally bioavailable, and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 6.06 nM for the human receptor).{41330} It is selective for the human 5-HT2A receptor over human 5-HT2B and 5-HT2C and rat 5-HT2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?-phenyl-1-(2-phenylethyl)-4-piperidinemethanol

Correlated keywords:

132553-86-7 MDL11939 glemanserin 5HT 5HT1A 5HT2A 5HT2B 5HT2C 11,939

Product Overview:
MDL 11939 is a potent, orally bioavailable, and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 6.06 nM for the human receptor).{41330} It is selective for the human 5-HT2A receptor over human 5-HT2B and 5-HT2C and rat 5-HT2B receptors (Kis = 3,020, 1,020, and 4,700 nM, respectively), as well as 5-HT1, 5-HT1A, α1- and α2-adrenergic, dopamine D2, muscarinic acetylcholine, histamine, and opiate receptors.{41330,41333} MDL 11939 administered to rats prior to or following learned helplessness-induced stress prevents increases in acoustic startle response.{41331} MDL 11939 (10 mg/kg, i.v.) also has anti-arrhythmic activity in anesthetized dogs following myocardial infarction.{41332}

Size	1 mg
Shipping	dry ice
CAS Number	107703-78-6
Molecular Formula	C₂₀H₂₅NO
SMILES	OC(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3
Molecular Weight	295,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.