5,6-dihydro-5-Fluorouracil

Biochemicals - Small Molecule Inhibitors

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Cat No: 20977

Biochemicals - Small Molecule Inhibitors

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil (5-FU; Item No. 14416) via the enzyme dihydropyrimidine dehydrogenase (DPD).{34392} Formulations containing 5-FU are used for the treatment of cancer. However, in pat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-fluorodihydro-2,4(1H,3H)-pyrimidinedione

Correlated keywords:

158250-33-0 5FUH2 5FUH-2 5FU

Product Overview:
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil (5-FU; Item No. 14416) via the enzyme dihydropyrimidine dehydrogenase (DPD).{34392} Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 µM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).{34391}

Size	5 mg
Shipping	dry ice
CAS Number	696-06-0
Molecular Formula	C₄H₅FN₂O₂
SMILES	O=C1NC(NCC1F)=O
Molecular Weight	132,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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