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Cholic Acid-d4

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    Cholic Acid-d<sub>4</sub>
  • Cholic Acid-d<sub>4</sub>
Cat No: 20849
Cayman

Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid.{52692} It is formed from cholesterol via a multistep process catalyzed by the cytoch...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (5?)-3?,7?,12?-trihydroxy-cholan-24-oic-2,2,4,4-d4 acid
Correlated keywords:
  • 116-68-7 10321-98-9 134353-30-3 728917-96-2 732303-80-9 882740-42-3 889875-66-5 904791-60-2 cholate cholbam E1000 NSC6135 E 1000 NSC 6135 NSC6135 deuterated deuterium GCMS LCMS cholalic cholalin Clostridium P 450 CYP 7A1 CYP7A-1 8B1 CYP8B CYP27A 27A1 AA
Product Overview:
Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid (Item No. 20250) by GC- or LC-MS. Cholic acid is a primary bile acid.{52692} It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; Item No. 20276) and taurocholic acid (TCA; Item No. 16215), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; Item No. 20756) by intestinal microbiota.{52692,61155,61156} It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v.{61157} Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.{61158}
Size 1 mg
Shipping dry ice
CAS Number 116380-66-6
Molecular Formula C24H36D4O5
SMILES O[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])C1([2H])[2H]
Molecular Weight 412,6
Formulation A crystalline solid
Purity ≥95%
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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