Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...More
|Antigen||This anti-Prion Protein Monoclonal Antibody was raised against an ovine recombinant protein.|
Reconstitute the content of the vial in 1 mL of water.
For western blot analysis of PrPc, dilute to a final concentration of 1 µg/mL and use BSA as blocking reagent. For EIA and flow cytometry, the optimal working must be determined empirically (currently between 0.1 and 1 µg/mL).
|Application Media||Reconstitute the content of the vial in 1 mL of water.|
|Formulation||lyophilized IgG with BSA|
Féraudet C., et al. Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells. The journal of Biological Chemistry. Vol. 280. No. 12, March 25, pp. 11247-11258, 2005.
Selective and Efficient Immunoprecipitation of the Disease-associated Form of the Prion Protein Can Be Mediated by Nonspecific Interactions between Monoclonal Antibodies and Scrapie-associated Fibrils.The journal of Biological Chemistry. Vol. 279. No. 29, July 16, pp. 30143-30149, 2004.