Prion Protein Monoclonal Antibody - BAR 233

Antibodies - Monoclonal Antibodies

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Cat No: A03223

Antibodies - Monoclonal Antibodies

€356.00

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Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...

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                        Territorial Availability: Available worldwide directly through Bertin or your local distributor
                    

Synonyms:

Prion Protein Monoclonal Antibody - BAR 233

Correlated keywords:

proteins

diseases

bovine

spongiform

encephalopathy

scrapie

Creutzfeldt-jakob

neurodegeneration

antibodies

antisera

antiserum

neurochemistry

neuroscience

spi-bio

spibio

A03200

Product Overview:
Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease.
This antibody recognises the protein sequence within amino acids 141-152 (human numbering).

Size	200 µg
Shipping	Dry Ice
Host	Mouse
Antigen	This anti-Prion Protein Monoclonal Antibody was raised against an ovine recombinant protein.
Clone	BAR233
Isotype	IgG2b
Application(s)	Reconstitute the content of the vial in 1 mL of water. For western blot analysis of PrPc, dilute to a final concentration of 1 µg/mL and use BSA as blocking reagent. For EIA and flow cytometry, the optimal working must be determined empirically (currently between 0.1 and 1 µg/mL).
Specificity	PrPc (NA) Hamster, (+) Mouse, (NA) Bovine, (+) Ovine, (+) Human.
Application Media	Reconstitute the content of the vial in 1 mL of water.
Formulation	lyophilized IgG with BSA
Custom Code	3822000000
UNSPSC code	12352203

Féraudet C., et al. Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells. The journal of Biological Chemistry. Vol. 280. No. 12, March 25, pp. 11247-11258, 2005.

Selective and Efficient Immunoprecipitation of the Disease-associated Form of the Prion Protein Can Be Mediated by Nonspecific Interactions between Monoclonal Antibodies and Scrapie-associated Fibrils.The journal of Biological Chemistry. Vol. 279. No. 29, July 16, pp. 30143-30149, 2004.

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