Rbin-1

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Rbin-1

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Cat No: 20745

Biochemicals - Small Molecule Inhibitors

Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.{32215} It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% whe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole

Correlated keywords:

Rbin1 mdn-1 mdn1F1093L Rsa-4 Rix-1 7 Ytm-1 Ppp-1 Nsa-1 mdn1ts Schizosaccharomyces

Product Overview:
Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.{32215} It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 µM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.

Size	1 mg
Shipping	dry ice
CAS Number	328023-11-6
Molecular Formula	C₁₃H₁₂N₄S
SMILES	C=C(C)CSC(N=N1)=NC2=C1C3=CC=CC=C3N2
Molecular Weight	256,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.