Hydrocortisone

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Hydrocortisone

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Cat No: 20739

Biochemicals - Lipids

Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).{11860,47112} It is an agonist at the mineralocorticoid receptor (MR) and the glucocorti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(11?)-11,17,21-trihydroxy-pregn-4-ene-3,20-dione

Correlated keywords:

8056-08-4 8063-42-1 80562-38-5 1050676-88-4 1436392-18-5 AC TH CCN 90306A NSC10483 U 1851 Acticort Aeroseb HC AlaCort Anflam CaldeCort Cetacort Cobadex CortDome Cortanal Cortef Cortenema Corticreme Cortifan Cortiment Cortispray Cortonema Cortril Dermacort Dermocortal Dermolate Dihydrocostisone Dioderm Domolene DuoCort Efcorbin Efcortelan Eldecort Epiderm H Esiderm Evacort Ficortril Genacort HidroColisona Hycort Hycortol Hycortole Hydracort Hydrasson HydroAdreson Hydrocort Hydrocortal Hydrocorticosterone Hydrocortin Hydrocortisyl Hydrocortone Hydroskin Hytone Incortin Infacort Lacticare Medicort Mildison Nutracort Optef Otosone-F Penecort Permicort Polcort Sanatison Scalpicin Scheroson Signef Synacort Tarcortin Timocort Topicort Traumaide Zenoxone

Product Overview:
Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).{11860,47112} It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor, with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.{47112} Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson’s disease.{11854,11861,47113}

Size	1 g
Shipping	room temp.
CAS Number	50-23-7
Molecular Formula	C₂₁H₃₀O₅
SMILES	[H][C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O
Molecular Weight	362,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2937.29
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.