Pyrrolidinedithiocarbamic Acid (ammonium salt)

Biochemicals - Small Molecule Inhibitors

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Cat No: 20713

Biochemicals - Small Molecule Inhibitors

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 µM).{33926} At 300 µM, it prevents TNF-α gene expression and protein production in human monocytes after LPS appli...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-pyrrolidinecarbodithioic acid, monoammonium salt

Correlated keywords:

31097-06-0 33497-70-0 50732-69-9 74776-29-7 149765-68-4 25769-03-3 APDC carboxylate carbodithioate TNF? TNF-a TNFa NFkB antiinflammatory anti-inflammatory anti-oxidant chelator lipopolysaccharide pyrrolidinedithiocarboxylate pyrrolidinedithiocarboxylic pyrrolidinecarbodithioate tumor necrosis factor G-1 p21-cip1

Product Overview:
Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 µM).{33926} At 300 µM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application.{33928} In vascular smooth muscle cells, PDTC (10 µM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway.{33925} PDTC (100 µM) also has antioxidant properties.{33927}

Size	10 g
Shipping	dry ice
CAS Number	5108-96-3
Molecular Formula	C₅H₈NS₂ • NH₄
SMILES	S=C([S-])N1CCCC1.[NH4+]
Molecular Weight	164,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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