Isoxsuprine (hydrochloride)

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Cat No: 20688

Biochemicals - Receptor Pharmacology

Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indic...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-hydroxy-?-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-benzenemethanol, monohydrochloride

Correlated keywords:

395-28-8 34233-88-0 34331-89-0 adrenergic ?-adrenergic b-adrenergic uterine anti-nociceptive preterm labor dilavase divadilan duvadilan duviculine isolait isoxsuprin isoxsuprine navilox suprilent suprox-sr tidilan vadosilan vasodilan vasoplex vasotran

Product Overview:
Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349
17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.

Size	5 g
Shipping	dry ice
CAS Number	579-56-6
Molecular Formula	C₁₈H₂₃NO₃ • HCl
SMILES	OC1=CC=C(C(O)C(C)NC(C)COC2=CC=CC=C2)C=C1.Cl
Molecular Weight	337,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.