Pyrroloquinoline quinone

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Cat No: 20681

Biochemicals - Natural Products

Pyrroloquinoline quinone (PQQ) is a quinone and redox enzyme cofactor that has been found in a variety of bacteria and has diverse biological activities.{43289,43290,43291,43292,43293} It inhibits fibril formation by the amyloid proteins amyloid-β (1-...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Correlated keywords:

124716-23-0 COX2 TNF? IL1? IL6 MCP1 MIP1? ?SMA A?-42 Iba1 Coenzyme Methoxatin Methoxatine 122628-50-6

Product Overview:
Pyrroloquinoline quinone (PQQ) is a quinone and redox enzyme cofactor that has been found in a variety of bacteria and has diverse biological activities.{43289,43290,43291,43292,43293} It inhibits fibril formation by the amyloid proteins amyloid-β (1-42) (Aβ42) and mouse prion protein when used at a concentrations of 100 and 300 μM.{43289} PQQ stimulates cell proliferation, reduces glutamate-induced production of reactive oxygen species (ROS), necrosis, and caspase-3 activity, and increases activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in neural stem and progenitor cells.{43290} It inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) and suppresses LPS-induced expression of the pro-inflammatory mediators iNOS, COX-2, TNF-α, IL-1β, IL-6, MCP-1, and MIP-1α in primary microglia.{43294} In vivo, PQQ (3 and 10 mg/kg) reduces Iba-1 expression, a marker of microglial activation, in the cerebral cortex and hippocampal dentate gyrus in mice. PQQ decreases the number of hepatic cells positive for α-smooth muscle actin (α-SMA) and reduces collagen deposition and hepatic hydroxyproline levels in a mouse model of liver fibrosis.{43292} It also decreases serum glucose and total cholesterol levels, increases brain SOD, CAT, and GPX activities, and decreases brain lipid hydroperoxide levels in mice with diabetes induced by streptozotocin (Item No. 13104).{43293}

Size	1 mg
Shipping	dry ice
CAS Number	72909-34-3
Molecular Formula	C₁₄H₆N₂O₈
SMILES	O=C(O)C1=C(C(NC(C(O)=O)=C2)=C2C(C3=O)=O)C3=NC(C(O)=O)=C1
Molecular Weight	330,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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