2'3'-cGAMP (sodium salt)

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Cat No: 19887

Biochemicals - More Biochemicals

2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.{22401,22400,29220} It contains a non-canonical 2’5’-phosphodiester bond and binds tightly to...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

adenylyl-(3'?5')-2'-guanylic acid, cyclic nucleotide, disodium salt

Correlated keywords:

1637247-71-2 STING cGAS interferon second messenger inducer IFNB GTP ATP cGMP synthase cyclic Gp(2'?5')Ap(3'?5') GpAP cGAMP(2'?5') IFN? 1441190-66-4

Product Overview:
2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.{22401,22400,29220} It contains a non-canonical 2’5’-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2’2’-cGAMP, 3’3’-cGAMP (Item No. 17966), cyclic di-GMP (Item No. 17144), and 3’2’-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively).{29220} It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.{29220}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₀H₂₂N₁₀O₁₃P₂ • 2Na
SMILES	O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]
Molecular Weight	718,4
Formulation	A solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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