Cridanimod (sodium salt)

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Cat No: 27884

Biochemicals - Anti-Infection

Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9-oxo-10(9H)-acridineacetic acid, monosodium salt

Correlated keywords:

38609-97-1 144696-36-6 351531-53-8 Camedon Camedone L 1 L1 Neovir CMA acridineacetate IRF 3 IFN? NF?B B 1

Product Overview:
Cridanimod is an inducer of type I interferon (IFN) production.{35839,50314} It induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in stimulator of interferon genes (STING) mutant, murine macrophages.{35839} In vivo, cridanimod (112-1,792 mg/kg) increases plasma levels of IFN in weanling and adult mice.{50314} Cridanimod inhibits viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses with protective doses (PD50s) ranging from 17-320 mg/kg.{48488} It increases uterine expression of estrogen and progesterone receptors in ovariectomized rats.{48489} Cridanimod also reverses tamoxifen-induced decreases in progesterone receptor expression in young rats.

Size	1 mg
Shipping	dry ice
CAS Number	58880-43-6
Molecular Formula	C₁₅H₁₀NO₃ • Na
SMILES	O=C1C2=CC=CC=C2N(CC([O-])=O)C3=C1C=CC=C3.[Na+]
Molecular Weight	275,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2918.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.