Paeonol

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Paeonol

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Cat No: 19862

Biochemicals - Natural Products

Paeonol is a phenol that has been found in Paeonia and has diverse biological activities.{31764,58139,31762,31761} It inhibits LPS- and IFN-γ-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentratio...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(2-hydroxy-4-methoxyphenyl)-ethanone

Correlated keywords:

phenolic NSC401442 peonol 1-2-hydroxy-4-methoxyphenyl-ethanone 2-acetyl-5-methoxyphenol 2-hydroxy-4-methoxyphenyl methyl ketone 4-methoxy-2-hydroxyacetophenone 4-O-methylresacetophenone 4'-methoxy-2'-hydroxyacetophenone paconol paeonolum resacetophenone 4-O-methyl ether anti-oxidative antiinflammatory antioxidant anti-oxidant hepato-protective

Product Overview:
Paeonol is a phenol that has been found in Paeonia and has diverse biological activities.{31764,58139,31762,31761} It inhibits LPS- and IFN-γ-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentrations of 10 and 30 µM.{31764} Paeonol inhibits histamine release from rat peritoneal mast cells induced by compound 48/80 (Item No. 22173) and reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock when administered at a dose of 0.5 mg per animal.{58139} It reduces hepatic necrosis and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024) when administered at a dose of 100 mg/kg.{31762} Paeonol (30, 50, and 100 mg/kg) inhibits carrageenan-induced thermal hyperalgesia and production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in rats.{31761}

Size	1 g
Shipping	room temp.
CAS Number	552-41-0
Molecular Formula	C₉H₁₀O₃
SMILES	OC1=C(C(C)=O)C=CC(OC)=C1
Molecular Weight	166,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.