Diosmin

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Diosmin

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Cat No: 19848

Biochemicals - Natural Products

Diosmin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{61083,61084,61085,61086,61087} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010), nitric oxide (NO), IL-12, IL-6, and TNF-α ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-[[6-O-(6-deoxy-?-L-mannopyranosyl)-?-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Correlated keywords:

9000-18-4 28680-33-3 flavone venous glycoside aglycone vasoprotective anti-mutagenic antiinflammatory prostaglandinE2 PGE2 PGE-2 thromboxaneA2 TXA2 teucrium gnaphalodes hesperidin ICAM1 VCAM1 ICAM-1 VCAM-1 P-glycoprotein pgp barosmin

Product Overview:
Diosmin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{61083,61084,61085,61086,61087} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010), nitric oxide (NO), IL-12, IL-6, and TNF-α in RAW 264.7 macrophages when used at concentrations ranging from 10 to 50 µM.{61083} Diosmin (100 mg/kg) reduces gastric ulcer area and leukocyte invasion in a rat model of ethanol-induced gastric injury.{61084} It decreases lung malondialdehyde (MDA) levels, increases lung glutathione (GSH) levels and catalase activity, and reduces fibrosis in a mouse model of paraquat-induced lung injury.{61085} Diosmin (50 and 100 mg/kg) increases the time spent in the goal quarter in a spatial memory test and reverses hippocampal dentate gyrus long term potentiation impairments in a rat model of scopolamine-induced cognitive impairment.{61086} It also reduces mechanical and thermal hyperalgesia in a rat model of neuropathic pain induced by chronic constriction injury.{61087}

Size	5 g
Shipping	dry ice
CAS Number	520-27-4
Molecular Formula	C₂₈H₃₂O₁₅
SMILES	OC1=C(C(C=C(C2=CC=C(OC)C(O)=C2)O3)=O)C3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=C1
Molecular Weight	608,5
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.