PTP Inhibitor I

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PTP Inhibitor I

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Cat No: 19766

Biochemicals - Small Molecule Inhibitors

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 µM and PTP1B with a Ki value o...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-bromo-1-(4-hydroxyphenyl)-ethanone

Correlated keywords:

protein tyrosine phosphatase SHP-1 PTP1B SHP1 PTP-1B PTP-1-B ?SH2 ?-SH2 ?SH-2 ?-SH-2 DSH2 DSH-2 D-SH2 D-SH-2 4'-hydroxy-2-bromoacetophenone busan 1130 busan 90 butrol 1130 busan1130 busan90 butrol1130 p-hydroxyphenacyl bromide ?-bromo-p-hydroxyacetophenone a-bromo-p-hydroxyacetophenone ?-bromo-phydroxyacetophenone w-bromo-phydroxyacetophenone Src homology region 2 domain-containing

Product Overview:
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 µM and PTP1B with a Ki value of 42 µM.{31401} SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}

Size	5 g
Shipping	room temp.
CAS Number	2491-38-5
Molecular Formula	C₈H₇BrO₂
SMILES	OC1=CC=C(C(CBr)=O)C=C1
Molecular Weight	215
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.