Podophyllotoxin

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Podophyllotoxin

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Cat No: 19575

Biochemicals - Natural Products

Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.{59991,59992,59993,59994,59995} It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the G2/M ph...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Correlated keywords:

11016-28-7 HSV1 anti-cancer Condyline Condylox NSC24818 Podofilox

Product Overview:
Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.{59991,59992,59993,59994,59995} It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the G2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/ml.{59992,59993} Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells.{59994} It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 µM).{59995} Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide (Item No. 12092) and teniposide (Item No. 14425).{31220} Formulations containing podophyllotoxin have been used in the treatment of external genital warts.

Size	100 mg
Shipping	dry ice
CAS Number	518-28-5
Molecular Formula	C₂₂H₂₂O₈
SMILES	O=C(OC1)[C@]([C@@]1([H])[C@H]2O)([H])C(C3=CC(OC)=C(OC)C(OC)=C3)C4=C2C=C(OCO5)C5=C4
Molecular Weight	414,4
Formulation	A powder
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.