Secoisolariciresinol Diglucoside

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Cat No: 24974

Biochemicals - Natural Products

Secoisolariciresinol diglucoside (SDG) is a lignan that has been found in flaxseed with antioxidant, antiproliferative, antidiabetic, and cardioprotective biological activities.{41788,41789,41790,41791,41792,41793} It scavenges 2,2-diphenyl-1-picrylhy...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediyl bis-?-D-glucopyranoside

Correlated keywords:

382135-57-1 148244-82-0 SW-480 MCF7 diglycoside

Product Overview:
Secoisolariciresinol diglucoside (SDG) is a lignan that has been found in flaxseed with antioxidant, antiproliferative, antidiabetic, and cardioprotective biological activities.{41788,41789,41790,41791,41792,41793} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 78.9 μg/ml) in a cell-free assay and dose-dependently inhibits the growth of SW480 human colon cancer cells in vitro.{41789,41790} Dietary administration of SDG reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen.{41791} It also increases insulin and decreases glucose serum levels in rats with diabetes induced by streptozotocin (Item No. 13104) when administered at a dose of 20 mg/kg.{41792} SDG (20 mg/kg per day) decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery.{41793}

Size	10 mg
Shipping	dry ice
CAS Number	158932-33-3
Molecular Formula	C₃₂H₄₆O₁₆
SMILES	O[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@H]1OC[C@]([C@@H](CC2=CC(OC)=C(O)C=C2)CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)([H])CC4=CC=C(O)C(OC)=C4
Molecular Weight	686,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.