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Nonactin, Monactin, and Dinactin Mixture

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    Nonactin, Monactin, and Dinactin Mixture
  • Nonactin, Monactin, and Dinactin Mixture
Cat No: 19468
Cayman

Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monov...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Correlated keywords:
  • 1400-56-2 6945-66-0 26082-94-0 6833-84-7 NSC52141 NSC56409 NSC-52141 56409 monovalent cation ionophore nonselective potassium ammonium titanium macrotetrolide Ammonium Ionophore I
Product Overview:
Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monovalent cations.{32001,32000,32002,43436,43437,32289} Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).{46583,46584} It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.{46583} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441} Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.{32291}
Size 5 mg
Shipping dry ice
CAS Number 6833-84-7
Molecular Formula C40H64O12 (for Nonactin)
SMILES O=C(O[C@@H](C)C[C@@]1([H])O[C@]([C@@H](C)C(O[C@H](C)C[C@]2([H])O[C@@]3([H])CC2)=O)([H])CC1)[C@@H](C)[C@]4([H])CC[C@@](C[C@@H](C)OC([C@H](C)[C@@]5([H])CC[C@](C[C@H](C)OC([C@H]3C)=O)([H])O5)=O)([H])O4
Molecular Weight 736,9
Formulation A crystalline solid
Purity ≥95% (mixture of homologues)
Custom Code 2918.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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