Griseofulvin

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Griseofulvin

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Cat No: 19461

Biochemicals - Lipids

Griseofulvin is a polyketide synthase-derived fungal metabolite originally isolated from P. griseofulvum with antifungal and anticancer activities.{60203,31420} It inhibits microtubule assembly when used at concentrations ranging from 20 to 200 µM.{62...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-chloro-2',4,6-trimethoxy-6'R-methyl-spiro[benzofuran-2(3H)-1'S-[2]cyclohexene]-3,4'-dione

Correlated keywords:

3426-54-8 8027-03-0 8055-10-5 11103-62-1 24659-79-8 amudane fulcin fulvicin fulvicin-P/G fulvicin-U/F fulvidex fulvina fulvinil fulvistatin gricin grifulin grifulvin grifulvin-V gris-PEG grisactin grisefulin griseovin grisofulvin grisovin grisovin-FP grysio idifulvin lamoryl likuden polygris poncyl poncyl-FP spirofulvin sporostatin xuanjing microtubule polymerizing agent anti-microtubule anti-biotic anti-fungal Penicillium HT29 COLO205

Product Overview:
Griseofulvin is a polyketide synthase-derived fungal metabolite originally isolated from P. griseofulvum with antifungal and anticancer activities.{60203,31420} It inhibits microtubule assembly when used at concentrations ranging from 20 to 200 µM.{62438} Griseofulvin is active against a variety of dermatophytes (MICs = 0.14-0.42 µg/ml) and reduces the number of infected hair follicles in a guinea pig model of M. canis infection when administered at a dose of 60 mg/kg.{62439,62440} It also reduces viability of a variety of human colorectal cancer cells in vitro and induces abnormal mitotic spindle formation and cell cycle arrest at the G2/M phase in HT-29 cells when used at a concentration of 20 µM.{59871} Griseofulvin (50 mg/kg) reduces tumor growth in a COLO 205 mouse xenograft model. Formulations containing griseofulvin have been used in the treatment of dermatophyte infections of the skin and nails.

Size	1 g
Shipping	dry ice
CAS Number	126-07-8
Molecular Formula	C₁₇H₁₇ClO₆
SMILES	COC1=C2C(O[C@@]3(C(OC)=CC(C[C@H]3C)=O)C2=O)=C(Cl)C(OC)=C1
Molecular Weight	352,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.