PRT4165

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PRT4165

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Cat No: 19093

Biochemicals - Small Molecule Inhibitors

BMI1/RING1A and BMI1/RNF2 are E3 ubiquitin ligase complexes that mediate the monoubiquitination of histone 2A (H2A). This is an essential function of polycomb repressive complex 1 (PRC1).{30718} PRT4165 is an inhibitor of the ubiquitin ligase activity ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3-pyridinylmethylene)-1H-indene-1,3(2H)-dione

Correlated keywords:

NSC600157 PRT-4165 ligase complex H2A RNF2 RING1 histone modification PRC1 PRC-1 polycomb repressive 1 BMI1/RING1A BMI1 RING1A BMI1RING1A BMI-1 RING-1A RING-1-A RING1-A RNF-2 2a

Product Overview:
BMI1/RING1A and BMI1/RNF2 are E3 ubiquitin ligase complexes that mediate the monoubiquitination of histone 2A (H2A). This is an essential function of polycomb repressive complex 1 (PRC1).{30718} PRT4165 is an inhibitor of the ubiquitin ligase activity of PRC1.{30882,30883} It blocks BMI1/RING1A self-ubiquitination (IC50 = 3.9 µM), as well as polyubiquitination of topoisomerase 2α in cells.{30882} PRT4165 inhibits ubiquitination of H2A by either RNF2 or RING1. Through these actions, PRT4165 prevents the accumulation of detectable ubiquitin at DNA double-strand breaks, the retention of response proteins around breaks, and the repair of breaks.{30883}

Size	5 mg
Shipping	dry ice
CAS Number	31083-55-3
Molecular Formula	C₁₅H₉NO₂
SMILES	O=C(C1=CC=CC=C1C/2=O)C2=C\C3=CC=CN=C3
Molecular Weight	235,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

Technical File

MSDS

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