SMER3

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SMER3

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Cat No: 15324

Biochemicals - Small Molecule Inhibitors

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response.{25205,25204} It is a small molecule enhancer of rapamycin (Item No. 13346), in that it...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9H-indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Correlated keywords:

1171832-66-8 inhibitors cancers cells cycles genes regulations intracellular signaling ubiquitin signals selective inhibits inhibitions SCFMet30 E3 E-3 E 3 ligases SMER-3 SMERs 3 three transcriptions cell-cycles controls immune responses upregulates up-regulates up regulates methionine biosynthesis genes complex prevents prevention preventing ubiquitination proteins Met4 Met-4 4 four proteasomes antagonists Skp1-Cullin-F-box (SCF)Met30 Skp1 Skp one Cullin F box SCF Met30 Met thirty small molecules enhancers rapamycin enhances yeasts cells cycles lethality tumorigenesis research

Product Overview:
SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response.{25205,25204} It is a small molecule enhancer of rapamycin (Item No. 13346), in that it enhances yeast cell lethality in response to rapamycin.{25205} SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4.{25205} As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.{25203}

Size	5 mg
Shipping	dry ice
CAS Number	67200-34-4
Molecular Formula	C₁₁H₄N₄O₂
SMILES	O=C1C2=NC3=NON=C3N=C2C4=C1C=CC=C4
Molecular Weight	224,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.