BMS 453

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BMS 453

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Cat No: 19076

Biochemicals - Receptor Pharmacology

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.{30780} It has been shown to ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid

Correlated keywords:

164108-16-1 BMS453 BMS189453 RARb RARaRARg RARag agonist antagonist RAR retinoic acid receptor

Product Overview:
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ.{30780} It has been shown to inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest.{30782} BMS 453 binding to RARα and RARγ can induce a transrepression of phorbol ester-induced AP-1 activity (IC50s = ~0.1 nM in HeLa and MCSF-7 cells), which also correlates with reduced cell proliferation.{30780} BM 453 has been used to trigger the differentiation of mouse embryonic stem cells (mES) in a study of RARβ-induced mES cell adipogenesis.{30781}

Size	1 mg
Shipping	dry ice
CAS Number	166977-43-1
Molecular Formula	C₂₇H₂₄O₂
SMILES	CC1(C)C2=C(C=C(/C=C/C3=CC=C(C(O)=O)C=C3)C=C2)C(C4=CC=CC=C4)=CC1
Molecular Weight	380,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2916.39
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.