AH 23848 (calcium salt)

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Cat No: 19023

Biochemicals - Receptor Pharmacology

Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH 23848 is a dual antagonist of TP and EP4 receptors.{3339,1755} It originally was found to inhibit TXA2-induced p...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4Z)-rel-7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid, hemicalcium salt

Correlated keywords:

81739-45-9 81443-73-4 AH23848 TXA-2 PGE-2 EP1 EP2 EP3 EP4 U46619

Product Overview:
Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH 23848 is a dual antagonist of TP and EP4 receptors.{3339,1755} It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 μM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619.{3339,1756} AH 23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4.{1755} By inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, and the proliferation of fibroblasts, as well as reduces metastasis in a mouse model of metastatic breast cancer.{16771,14694}

Size	1 mg
Shipping	dry ice
CAS Number	81496-19-7
Molecular Formula	C₂₉H₃₄NO₅ • 1/2Ca
SMILES	O=C1C[C@H](OCC2=CC=C(C3=CC=CC=C3)C=C2)[C@H](CC/C=C\CCC([O-])=O)[C@H]1N4CCOCC4.O=C5C[C@H](OCC6=CC=C(C7=CC=CC=C7)C=C6)[C@H](CC/C=C\CCC([O-])=O)[C@H]5N8CCOCC8.[Ca+2]
Molecular Weight	496,6
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2933.59
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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