Carbocyclic Thromboxane A₂

Biochemicals - Lipids

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Cat No: 19010

Biochemicals - Lipids

Carbocyclic thromboxane A2 (CTA2) is a stable analog of TXA2. CTA2 is a potent coronary vasoconstrictor and is effective at concentrations as low as 1 nM in cat coronary arteries.{333} Unlike other vascular TP receptor agonists, CTA2 is a potent inhib...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(5Z)-7-[(2S,3R)-3-[(1E,3S)-3-hydroxy-1-octen-1-yl]bicyclo[3.1.1]hept-2-yl]-5-heptenoic acid

Correlated keywords:

CTA-2 TXA-2 TXB-2

Product Overview:
Carbocyclic thromboxane A2 (CTA2) is a stable analog of TXA2. CTA2 is a potent coronary vasoconstrictor and is effective at concentrations as low as 1 nM in cat coronary arteries.{333} Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation. It inhibits arachidonic acid-induced aggregation with an IC50 value of 4-5 µM. CTA2 also exhibits selective and dose-dependent inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 µM.{333}

Size	100 µg
Shipping	dry ice
CAS Number	74034-56-3
Molecular Formula	C₂₂H₃₆O₃
SMILES	CCCCC[C@H](O)/C=C/[C@H]1C[C@H]2C[C@H](C2)[C@@H]1C/C=C\CCCC(O)=O
Molecular Weight	348,5
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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