PF-CBP1

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PF-CBP1

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Cat No: 18811

Biochemicals - Small Molecule Inhibitors

CREB-binding protein (CBP) and E1A-associated protein p300 are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.{22609,22611} Both CBP and p300 contain bromodomains, which mediate the...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole

Correlated keywords:

PFCBP1 CBP p300 bromodomain CREB binding protein CREBBP PF-CBP-1 PFCBP-1 RGS-4 cAMP-responsive element

Product Overview:
CREB-binding protein (CBP) and E1A-associated protein p300 are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development.{22609,22611} Both CBP and p300 contain bromodomains, which mediate their binding to acetylated lysine residues on histones and other proteins.{21581} PF-CBP1 is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively).{30310} It displays greater than 100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins.{30310} PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages.{30310} It also suppresses the expression of RGS4 (regulator of G protein signaling 4) in primary cortical neurons.{30310}

Size	500 µg
Shipping	dry ice
CAS Number	1962928-21-7
Molecular Formula	C₂₉H₃₆N₄O₃
SMILES	CCCOC(C=C1)=CC=C1CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5
Molecular Weight	488,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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