Mitotane

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Mitotane

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Cat No: 18651

Biochemicals - Small Molecule Inhibitors

Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells.{30365,30364} It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene

Correlated keywords:

102976-59-0 CB 313 CB313 chloditane mitotan NSC38721 opeprim opDDD o,p'-dichlorodiphenyldichloroethane o,p'-TDE opTDE antineoplastic lysodren chlodithane 2,4?-DDD 24DDD (2,4?-dichlorodiphenyl)dichloroethane 2,4?-dichlorodiphenyldichloroethane 2,4?-dichloro diphenyldichloroethane hydroxyprogesterone H295 R H 295R 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane

Product Overview:
Mitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells.{30365,30364} It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells.{30365,30364} Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system.{30367,30366} It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.{30366,24098}

Size	100 mg
Shipping	dry ice
CAS Number	53-19-0
Molecular Formula	C₁₄H₁₀Cl₄
SMILES	ClC1=CC=C(C(C(Cl)Cl)C2=CC=CC=C2Cl)C=C1
Molecular Weight	320
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.